diff --git a/CHANGELOG.md b/CHANGELOG.md
index cc180a6..1ba4252 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,12 +10,14 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ### Fixed
 
 - Ensure `DialogPanel` exposes its ref ([#1404](https://github.com/tailwindlabs/headlessui/pull/1404))
+- Ignore `Escape` when event got prevented in `Dialog` component ([#1424](https://github.com/tailwindlabs/headlessui/pull/1424))
 
 ## [Unreleased - @headlessui/react]
 
 ### Fixed
 
 - Fix closing of `Popover.Panel` in React 18 ([#1409](https://github.com/tailwindlabs/headlessui/pull/1409))
+- Ignore `Escape` when event got prevented in `Dialog` component ([#1424](https://github.com/tailwindlabs/headlessui/pull/1424))
 
 ## [@headlessui/react@1.6.1] - 2022-05-03
 
diff --git a/packages/@headlessui-react/src/components/dialog/dialog.tsx b/packages/@headlessui-react/src/components/dialog/dialog.tsx
index f5d7424..d7968be 100644
--- a/packages/@headlessui-react/src/components/dialog/dialog.tsx
+++ b/packages/@headlessui-react/src/components/dialog/dialog.tsx
@@ -237,6 +237,7 @@ let DialogRoot = forwardRefWithAs(function Dialog<
 
   // Handle `Escape` to close
   useEventListener(ownerDocument?.defaultView, 'keydown', (event) => {
+    if (event.defaultPrevented) return
     if (event.key !== Keys.Escape) return
     if (dialogState !== DialogStates.Open) return
     if (hasNestedDialogs) return
diff --git a/packages/@headlessui-vue/src/components/dialog/dialog.ts b/packages/@headlessui-vue/src/components/dialog/dialog.ts
index 56dce24..b02897b 100644
--- a/packages/@headlessui-vue/src/components/dialog/dialog.ts
+++ b/packages/@headlessui-vue/src/components/dialog/dialog.ts
@@ -212,6 +212,7 @@ export let Dialog = defineComponent({
 
     // Handle `Escape` to close
     useEventListener(ownerDocument.value?.defaultView, 'keydown', (event) => {
+      if (event.defaultPrevented) return
       if (event.key !== Keys.Escape) return
       if (dialogState.value !== DialogStates.Open) return
       if (hasNestedDialogs.value) return