diff --git a/packages/@headlessui-react/src/components/combobox/combobox.tsx b/packages/@headlessui-react/src/components/combobox/combobox.tsx
index 8b68ced..479f2e2 100644
--- a/packages/@headlessui-react/src/components/combobox/combobox.tsx
+++ b/packages/@headlessui-react/src/components/combobox/combobox.tsx
@@ -1576,6 +1576,11 @@ function OptionsFn<TTag extends ElementType = typeof DEFAULT_OPTIONS_TAG>(
   let actions = useActions('Combobox.Options')
   let anchor = useResolvedAnchor(rawAnchor)
 
+  // Always enable `portal` functionality, when `anchor` is enabled
+  if (anchor) {
+    portal = true
+  }
+
   let [floatingRef, style] = useFloatingPanel(anchor)
   let getFloatingPanelProps = useFloatingPanelProps()
   let optionsRef = useSyncRefs(data.optionsRef, ref, anchor ? floatingRef : null)